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1

Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki–Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle

Maria-João R.P. Queiroz, Ricardo C. Calhelha, Luís A. Vale-Silva, Eugénia Pinto, Raquel T. Lima, M. Helena Vasconcelos

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 602 KB

english, 2010

2

Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography

Eugénia Pinto, Carlos Afonso, Serafim Duarte, Luís Vale-Silva, Elisangela Costa, Emília Sousa, Madalena Pinto

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 332 KB

english, 2011

3

Antifungal activity of phenolic-richLavandula multifidaL. essential oil

Zuzarte, M., Vale-Silva, L., Gonçalves, M. J., Cavaleiro, C., Vaz, S., Canhoto, J., Pinto, E., Salgueiro, L.

Journal:

European Journal of Clinical Microbiology & Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 179 KB

english, 2012

4

Correlation of the chemical composition of essential oils from Origanum vulgare subsp. virens with their in vitro activity against pathogenic yeasts and filamentous fungi

Vale-Silva, L., Silva, M.-J., Oliveira, D., Goncalves, M.-J., Cavaleiro, C., Salgueiro, L., Pinto, E.

Journal:

Journal of Medical Microbiology

Year:

2012

Language:

english

File:

PDF, 149 KB

english, 2012

5

ChemInform Abstract: Synthesis of Novel 3-(Aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira Products and Intramolecular Cyclization: Antitumoral Activity Evaluation.

Maria-Joao R. P. Queiroz, Ricardo C. Calhelha, Luis A. Vale-Silva, Eugenia Pinto, M. Sao-Jose Nascimento

Journal:

Year:

2009

File:

PDF, 27 KB

2009

6

ChemInform Abstract: Efficient Synthesis of 6-(Hetero)arylthieno[3,2-b]pyridines by Suzuki—Miyaura Coupling. Evaluation of Growth Inhibition on Human Tumor Cell Lines, SARs and Effects on the Cell Cycle.

Maria-Joao R. P. Queiroz, Ricardo C. Calhelha, Luis A. Vale-Silva, Eugenia Pinto, Raquel T. Lima, M. Helena Vasconcelos

Journal:

Year:

2011

Language:

english

File:

PDF, 32 KB

english, 2011

7

ChemInform Abstract: Synthesis and Evaluation of Tumor Cell Growth Inhibition of Methyl 3-Amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure—Activity Relationships, Effects on the Cell Cycle and Apoptosis.

Maria-Joao R. P. Queiroz, Ricardo C. Calhelha, Luis A. Vale-Silva, Eugenia Pinto, Gabriela M. Almeida, M. Helena Vasconcelos

Journal:

Year:

2011

File:

PDF, 51 KB

2011

8

Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety

Eugénia Pinto, Maria-João R.P. Queiroz, Luís A. Vale-Silva, João F. Oliveira, Agathe Begouin, Jeanne-Marie Begouin, Gilbert Kirsch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 226 KB

english, 2008

9

Investigation of the mechanism of action of 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans by flow cytometry

Luís A. Vale-Silva, Vladimír Buchta, Doris Vokurková, Milan Pour

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 134 KB

english, 2006

10

Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation

Maria-João R.P. Queiroz, Ricardo C. Calhelha, Luís A. Vale-Silva, Eugénia Pinto, M. São-José Nascimento

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 550 KB

english, 2009

11

Novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines: Synthesis and antitumoral activities

Maria-João R.P. Queiroz, Ricardo C. Calhelha, Luís A. Vale-Silva, Eugénia Pinto, M. São-José Nascimento

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 734 KB

english, 2010

12

Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure–activity relationships, effects on the cell cycle and apoptosis

Maria-João R.P. Queiroz, Ricardo C. Calhelha, Luís A. Vale-Silva, Eugénia Pinto, Gabriela M. Almeida, M. Helena Vasconcelos

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 205 KB

english, 2011

13

Effect of subinhibitory concentration of some established and experimental antifungal compounds on the germ tube formation inCandida albicans

L. A. Vale-Silva, V. Buchta, E. Valentová

Journal:

Folia Microbiologica

Year:

2007

Language:

english

File:

PDF, 137 KB

english, 2007

14

Antifungal susceptibility testing by flow cytometry: is it the future?

Luís André Vale-Silva, Vladimír Buchta

Journal:

Year:

2006

Language:

english

File:

PDF, 196 KB

english, 2006

15

Comparison of the Etest and a rapid flow cytometry-based method with the reference CLSI broth microdilution protocol M27-A3 for the echinocandin susceptibility testing ofCandidaspp.

Vale-Silva, L. A., Pinto, P., Lopes, V., Ramos, H., Pinto, E.

Journal:

European Journal of Clinical Microbiology & Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 186 KB

english, 2012

16

New potential antitumoral di(hetero)arylether derivatives in the thieno[3,2-b]pyridine series: Synthesis and fluorescence studies in solution and in nanoliposomes

Maria-João R.P. Queiroz, Sofia Dias, Daniela Peixoto, Ana Rita O. Rodrigues, Andreia D.S. Oliveira, Paulo J.G. Coutinho, Luís A. Vale-Silva, Eugénia Pinto, Elisabete M.S. Castanheira

Journal:

Journal of Photochemistry and Photobiology A: Chemistry

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

17

Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate

Ana S Abreu, Elisabete MS Castanheira, Maria-João RP Queiroz, Paula MT Ferreira, Luís A Vale-Silva, Eugénia Pinto

Journal:

Nanoscale Research Letters

Year:

2011

Language:

english

File:

PDF, 217 KB

english, 2011

18

Interaction of antitumoral fluorescent heteroaromatic compounds, a benzothienopyrrole and two thienoindoles, with DNA and lipid membranes

Ana S. Abreu, Elisabete M.S. Castanheira, Paulo J.G. Coutinho, Maria-João R.P. Queiroz, Paula M.T. Ferreira, Luís A. Vale-Silva, Eugénia Pinto

Journal:

Journal of Photochemistry and Photobiology A: Chemistry

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

19

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Her.

Zuzarte, M., Goncalves, M. J., Cavaleiro, C., Canhoto, J., Vale-Silva, L., Silva, M. J., Pinto, E., Salgueiro, L.

Journal:

Journal of Medical Microbiology

Year:

2011

Language:

english

File:

PDF, 199 KB

english, 2011

20

Aspergillus viridinutans : an agent of adult chronic invasive aspergillosis

Coelho, Danina, Silva, Susana, Vale-Silva, Luís, Gomes, Helena, Pinto, Eugénia, Sarmento, António, Pinheiro, Maria Dolores

Journal:

Medical Mycology

Year:

2011

Language:

english

File:

PDF, 339 KB

english, 2011

21

Antifungal activity of the essential oil of Thymus villosus subsp. lusitanicus against Candida, Cryptococcus, Aspergillus and dermatophyte species

Pinto, Eugénia, Gonçalves, Maria José, Hrimpeng, Karnjana, Pinto, Jéssica, Vaz, Sara, Vale-Silva, Luís André, Cavaleiro, Carlos, Salgueiro, Lígia

Journal:

Industrial Crops and Products

Year:

2013

Language:

english

File:

PDF, 737 KB

english, 2013

22

Lycopersicon esculentum Seeds: An Industrial Byproduct as an Antimicrobial Agent

Taveira, Marcos, Silva, Luís R., Vale-Silva, Luís A., Pinto, Eugénia, Valentão, Patrícia, Ferreres, Federico, Guedes de Pinho, Paula, Andrade, Paula B.

Journal:

Journal of Agricultural and Food Chemistry

Year:

2010

Language:

english

File:

PDF, 830 KB

english, 2010

23

Molecular Mechanisms of Drug Resistance in Clinical Candida Species Isolated from Tunisian Hospitals

Eddouzi, J., Parker, J. E., Vale-Silva, L. A., Coste, A., Ischer, F., Kelly, S., Manai, M., Sanglard, D.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

24

Evaluation of Etest Performed in Mueller–Hinton Agar Supplemented with Glucose for Antifungal Susceptibility Testing of Clinical Isolates of Filamentous Fungi

Pinto, E., Lago, M., Branco, L., Vale-Silva, L. A., Pinheiro, M. D.

Journal:

Year:

2014

Language:

english

File:

PDF, 194 KB

english, 2014

25

Targeted Metabolite Analysis and Biological Activity of Pieris brassicae Fed with Brassica rapa var. rapa

Pereira, David M., Noites, Alexandra, Valentão, Patricia, Ferreres, Federico, Pereira, José A., Vale-Silva, Luis, Pinto, Eugénia, Andrade, Paula B.

Journal:

Journal of Agricultural and Food Chemistry

Year:

2009

Language:

english

File:

PDF, 822 KB

english, 2009

26

Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species

Pinto, E., Vale-Silva, L., Cavaleiro, C., Salgueiro, L.

Journal:

Journal of Medical Microbiology

Year:

2009

Language:

english

File:

PDF, 213 KB

english, 2009

27

Gain-of-Function Mutations in PDR1, a Regulator of Antifungal Drug Resistance in Candida glabrata, Control Adherence to Host Cells

Vale-Silva, L., Ischer, F., Leibundgut-Landmann, S., Sanglard, D.

Journal:

Infection and Immunity

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

28

Azole Resistance by Loss of Function of the Sterol 5,6-Desaturase Gene (ERG3) in Candida albicans Does Not Necessarily Decrease Virulence

Vale-Silva, L. A., Coste, A. T., Ischer, F., Parker, J. E., Kelly, S. L., Pinto, E., Sanglard, D.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2012

Language:

english

File:

PDF, 1017 KB

english, 2012

29

Tipping the balance both ways: drug resistance and virulence in Candida glabrata

Vale-Silva, L. A., Sanglard, D.

Journal:

FEMS Yeast Research

Year:

2015

Language:

english

File:

PDF, 229 KB

english, 2015

30

Antifungal Activity of the Essential Oil of Thymus x viciosoi against Candida, Cryptococcus, Aspergillus and Dermatophyte Species

Vale-Silva, Luís, Gonçalves, Maria, Cavaleiro, Carlos, Salgueiro, Lígia, Pinto, Eugénia

Journal:

Year:

2010

File:

PDF, 152 KB

2010

31

Antifungal Activity of the Essential Oil of Thymus x viciosoi against Candida, Cryptococcus, Aspergillus and Dermatophyte Species

Vale-Silva, Luís, Gonçalves, Maria, Cavaleiro, Carlos, Salgueiro, Lígia, Pinto, Eugénia

Journal:

Year:

2010

Language:

english

File:

PDF, 152 KB

english, 2010

32

Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction

Nishikawa, Joy L., Boeszoermenyi, Andras, Vale-Silva, Luis A., Torelli, Riccardo, Posteraro, Brunella, Sohn, Yoo-Jin, Ji, Fei, Gelev, Vladimir, Sanglard, Dominique, Sanguinetti, Maurizio, Sadreyev, Ru

Journal:

Year:

2016

Language:

english

File:

PDF, 8.30 MB

english, 2016

33

Upregulation of the Adhesin Gene EPA1 Mediated by PDR1 in Candida glabrata Leads to Enhanced Host Colonization

Vale-Silva, Luis A., Moeckli, Beat, Torelli, Riccardo, Posteraro, Brunella, Sanguinetti, Maurizio, Sanglard, Dominique, Lorenz, Michael

Journal:

Year:

2016

Language:

english

File:

PDF, 1.73 MB

english, 2016

34

Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells

Calhelha, Ricardo C., Ferreira, Isabel C. F. R., Peixoto, Daniela, Abreu, Rui M. V., Vale-Silva, Luís A., Pinto, Eugénia, Lima, Raquel T., Alvelos, M. Inês, Vasconcelos, M. Helena, Queiroz, Maria-João

Journal:

Year:

2012

Language:

english

File:

PDF, 187 KB

english, 2012

35

Comparative Genomics of Two Sequential Candida glabrate Clinical Isolates

Vale-Silva, Luis, Beaudoing, Emmanuel, Tran, Van Du T., Sanglard, Dominique

Journal:

G3 Genes|Genome|Genetics

Year:

2017

Language:

english

File:

PDF, 984 KB

english, 2017

36

SNP-ChIP: a versatile and tag-free method to quantify changes in protein binding across the genome

Vale-Silva, Luis A., Markowitz, Tovah E., Hochwagen, Andreas

Journal:

Year:

2019

Language:

english

File:

PDF, 3.65 MB

english, 2019

37

Stem cell-derived polarized hepatocytes

Dao Thi, Viet Loan, Wu, Xianfang, Belote, Rachel L., Andreo, Ursula, Takacs, Constantin N., Fernandez, Joseph P., Vale-Silva, Luis Andre, Prallet, Sarah, Decker, Charlotte C., Fu, Rebecca M., Qu, Bing

Journal:

Nature Communications

Year:

2020

File:

PDF, 3.21 MB

2020

38

Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae

Heldrich, Jonna, Sun, Xiaoji, Vale-Silva, Luis A., Markowitz, Tovah E., Hochwagen, Andreas

Journal:

Year:

2020

File:

PDF, 2.26 MB

2020